What do you think of JUVGEN? Before “autologous dermal regeneration”

Moving beyond the “repetition” of hyaluronic acid. Aiming for natural youthfulness by unlocking the skin’s inherent power,

the skin booster “Juvezen” is gaining attention

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Table of Contents

1. Say goodbye to repeated hyaluronic acid treatments! The innovative “Juvezen” technology that rejuvenates your skin using your own skin
2. We found the real answer to nasolabial folds that won’t disappear no matter what you do💫
3. 🔬 What is Juvezen? 3 revolutionary points
4. ① The concept of “regeneration,” not replenishment

Open Table of Contents

 For nasolabial folds that never became less noticeable no matter what I tried,a new optionhas been found💫

“Even after getting hyaluronic acid injections, everything returns to how it was within a few months…”

“No matter how many laser treatments I receive, I find it difficult to see results for deep wrinkles”

“My crater-like acne scars have barely changed for more than 10 years”

For those struggling with concerns like these, there is a treatment I want you to know about.

It originated in Gangnam, South Korea:

“JUVGEN Autologous Dermal Regeneration Treatment.”

While conventional aesthetic treatments have mainly focused on “filling in” or “temporarily improving” the skin,

JUVGEN is attracting attention as a treatment that works on the inside of the skin (the dermis) and aims to create change from the foundation up.

It uses the body’s own functions to promote collagen production and support the formation of new dermal tissue—

it can also be described as an “autologous regenerative approach” inspired by the principles of regenerative medicine.

“I feel that repeated care has reached its limits”

“I want to aim for long-term improvement through natural-looking changes”

For those people, it may be an option worth considering at least once✨

※The suitability, effects, and duration of treatment vary from person to person. Please consult with a doctor after an examination to discuss the method that is right for you.

🔬 What is JUVGEN? 3 key points to note

JUVGEN is one of the treatments introduced as an approach that aims to regenerate the skin by acting on the dermis.

It is sometimes based on the concept of “self-dermal regeneration,” and is characterized by an approach different from conventional injection treatments.

While hyaluronic acid and Botox mainly take an approach of “refining the surface,”

JUVGEN has attracted attention because it is closer to the idea of improving the foundation of the skin—the dermis—to address skin concerns.

① The concept of “promoting regeneration” rather than “supplementing”

Hyaluronic acid is a treatment that supplements volume by injecting an ingredient from outside the body.

In contrast, JUVGEN is considered an approach that aims to bring out the skin’s natural changes by promoting collagen production within the skin and improving the dermal environment.

Rather than creating contours from the outside, it aims to bring about changes in the skin itself,

which has drawn interest as an option for those who prioritize a more natural-looking result.

② The ability to consider the duration of effects from a long-term perspective

The effects of hyaluronic acid and Botox tend to change over time,

This is a treatment that often requires regular maintenance.

JUVGEN is designed to work on the foundation of the skin,

and is characterized by making it easier to consider the duration of its effects from a medium- to long-term perspective rather than a short-term one.

※The way effects appear, duration of effects, and number of treatments required vary from person to person.

It is important to consult with a doctor about a treatment plan suited to you after receiving a medical examination.

③ Technical background and the fact that clinical reports have been introduced

JUVGEN may be introduced through information regarding patents, academic reports, media coverage, and more.

However, the content and scope of the information vary depending on the materials and sources, so it is important to verify it based on primary sources such as official information and academic papers.

 When considering treatment, checking the source of the information and making a decision after receiving a thorough explanation from a doctor can provide peace of mind.

👨‍⚕️ The developer is a specialist with extensive clinical experience

JUVGEN (JUVGEN) was developed by Dr. Chin Se-hoon, who is introduced as the director of a clinic in Gangnam, Seoul, South Korea, where he has practiced for many years.

While addressing skin concerns such as wrinkles, scars, and acne scars over many years, he is said to have accumulated research and clinical experience and systematized his techniques and approach.

Initiatives and information related to JUVGEN have also been featured in various media outlets and official communications, and the idea of “bringing out changes in the skin” rather than “補う” can be considered one of the factors behind the attention it has attracted.

Outstanding experience and track record

Dr. Chin is introduced as a specialist who has been involved in wrinkle and scar treatments for many years.

Some introductions state that he has 34 years of clinical experience, has been involved in more than 5,000 procedures and established JUVGEN after approximately 15 years of research.

It is also said that during the development process, Director Chin explained the concept by performing the treatment on one side of his own face and demonstrating the difference between the two sides—an episode that has been shared.

This attitude of “trying it on oneself first” can be considered one of the factors that helps people understand the treatment and feel reassured.

Also Attracting Attention in the Media

Juvzen is said to have been featured on a medical program on KBS, South Korea’s national broadcaster, which is said to have helped make the treatment more widely known.

The idea of “working on the inside of the skin” rather than “replenishing” has attracted attention as a perspective different from conventional injection treatments, and is gaining interest as one possible option.

It has also been introduced that patients visit from overseas, including Japan, China, and Southeast Asia, not only from within South Korea.

Some are said to travel from far away for consultations, suggesting that more people are seeking information across borders.

💉 The Mechanism of Juvzen: How Does It Approach the Skin’s “Foundation”?

One of Juvzen’s features is its treatment design, which is said to use a uniquely developed “dual-chamber syringe.”

Patented Technology: Dual-Chamber Syringe

This syringe is equipped with two chambers, each of which is described as containing a different component.

• First chamber: Carbon dioxide (CO₂)
• Second chamber: Hyaluronic acid

The design is described as injecting these components in very small amounts, adjusted to the treatment area and condition, with the aim of delivering them evenly to the targeted layer.

(※ The injection amount and method vary according to the doctor’s judgment and individual differences.)

3 Functions (Points Explained as Effects)

Jubzen is sometimes described as being intended to produce the following effects within the skin after the procedure.

 ① Physical stimulation

The stimulation caused by microinjections creates an opportunity to promote remodeling (reconstruction) within the skin.

② Approach to changes in the environment

The injection of CO₂ aims to create changes in the local environment and elicit responses related to circulation.

③ Action on fibroblasts

Focusing on the function of fibroblasts, it aims to support the production of collagen and other substances.

Targeted results: Natural firmness and smoothness

Through these effects, it is introduced as a procedure that aims to improve the skin’s firmness and smoothness from its foundation.

Since the way effects are perceived and how long they last varies from person to person, those who are interested are advised to consult a doctor and confirm whether the procedure is suitable for them.

📊 How It Differs from Other Procedures｜What Makes Jubzen Different?

There are various ways to care for nasolabial folds and wrinkles, but what are the distinctive features of Jubzen?

Let’s organize the differences in approach compared with representative procedures.

Difference from Hyaluronic Acid (Comparison of Approaches)

Hyaluronic acid

• Approach: Adds volume (supplementing from the outside)
• How changes appear: Relatively quick and easy to notice
• Duration: Several months or longer (varies by individual)
• Maintenance: Additional treatment may be recommended depending on the condition
• Suitable cases: Adjusting hollows, lack of volume, etc.

ジュブゼン（JUVGEN）

• Approach: Designed to target the foundation of the skin (the dermal layer) (it may be described as aiming to promote reconstruction)
• How changes appear: Many cases involve gradually noticeable changes
• Duration: Introduced as a treatment aiming for long-term changes (individual results may vary)
• Maintenance: May be described as designed without assuming frequent additional treatments
• Suitable cases: When you want to improve deeper wrinkles or hollows “from the foundation up,” etc. (suitability is determined by a doctor)

Hyaluronic acid is often chosen when you want to “make adjustments right away” or “adjust volume,” but depending on the condition, regular maintenance may be required.

On the other hand, with ジュブゼン, it may take time before you notice changes, but it may be introduced as a treatment designed to target the foundation of the skin. Some people consider it when they want to improve their appearance “over the medium to long term rather than in the short term.”

Rather than one being superior to the other, the key is to choose based on “what concern you want to address and how you want to improve it.”

Differences from Botox

Botox

・Approach: Makes wrinkles less noticeable by reducing muscle movement

・Duration of effects: Generally approximately 3–4 months (individual results may vary)

・Indications: Dynamic wrinkles (forehead, glabella, crow’s feet, etc.)

・Effect on deep hollows: Not intended to fill the hollows themselves

ジュブゼン

・Approach: Aims to influence the dermal environment and bring about changes in the skin (※as introduced)

・Duration of effects: Said to last longer (※individual results and conditions apply)

・Indications: May be introduced as an option for concerns such as deep wrinkles, a hollowed appearance, and scars

・Effect on deep hollows: Improvement may be expected in some cases depending on the condition (※medical consultation required)

While Botox is used to improve expression lines, it is not a treatment intended to fill deeply etched nasolabial folds or depressions themselves.

Juvzen is introduced as a treatment that aims to bring about changes from the foundation of the skin by targeting the dermis, and may be considered as one option for addressing deeper concerns.

※Indications, effects, and duration vary from person to person. Please consult with a doctor about the most suitable method after an examination.

Difference from Laser Treatments

Laser Treatment

・Approach: Applies thermal stimulation to the skin surface to shallow layers, aiming to improve skin quality

・Duration of effects: Several months to approximately 1 year (varies depending on the treatment and individual)

・Effect on deep depressions: May be limited depending on the condition

・Downtime: May range from several days to approximately 1–2 weeks depending on the treatment

Juvzen

・Approach: Aims to induce changes in the skin by working on the dermal environment (※as described in introductions)

・Duration of effects: Considered to last for a longer period (※individual and other conditions apply)

・Effect on deep depressions: There are cases where improvement may be expected depending on the condition (※medical consultation required)

・Downtime: Considered to be relatively minimal (※redness, swelling, or other symptoms may occur)

While lasers are used as treatments aimed at improving shallow wrinkles and skin quality,

for deep crater-like depressions and deeply etched nasolabial folds,

expectations may be limited (depending on the condition and type of laser).

Juvzen is introduced as a treatment that aims to bring about changes from the foundation by targeting the dermis,

and may be considered as an option for more serious concerns.

⏰ Timeframe and Progress Until Effects Appear

Juvzen is not a treatment that produces dramatic changes immediately after the procedure.

On the other hand, it is introduced as a treatment that aims to bring about gradual changes over time by targeting the foundation of the skin (the dermis).

※The course of progress and how the effects are perceived vary from person to person

Immediately After the Procedure to 2 Weeks (Approximate)

Immediately after the procedure, the injected product may temporarily create a fuller appearance.

However, this change may also be temporary.

It is sometimes explained that reactions related to collagen production begin to progress around 2 weeks after the procedure,

so even if visible changes are minor, changes may be progressing beneath the skin.

Around 1 Month: When You May Begin to Notice Changes (Approximate)

After around 1 month,

some people are said to notice changes such as

“Nasolabial folds feel slightly shallower”

“I feel like my skin has become firmer”

.

There are also explanations suggesting that from this point onward, more people begin to notice changes in their skin texture and overall appearance.

Around 3 Months: The Period Often Described as the Peak (Approximate)

Around 3 months after the procedure is sometimes described as the peak of the changes.

It is also sometimes introduced as the time when increased collagen production makes it easier to notice improved skin firmness and smoothness.

※However, the degree of improvement (nasolabial folds, depressions, and skin quality) varies depending on the condition, individual constitution, and treatment plan.

After 6 Months: Maintenance and Follow-Up Observation (Approximate)

While the changes are said to be maintained even after the peak, age-related changes naturally progress,

Depending on your condition, additional care or follow-up observation may be recommended.

Since “how long the effects can be maintained” and “how many treatments are needed” vary greatly from person to person,

it is important to create a plan that suits you while consulting with a doctor.

Frequently Asked Questions Q&A

Q1. Is Juvuzhen painful?

A. Since the procedure involves injections, you may feel some stimulation.

However, very fine needles are used, and the product is injected carefully according to the treatment area and condition, so many people report that it was less burdensome than they had imagined.

If you are concerned, topical or cream anesthesia can also be used.

Q2. How long does it take for the effects to appear?

A. Although there are individual differences, many people are told that they may begin to notice changes around one month after treatment,

and in some cases, around three months is described as the peak of the changes.

Rather than being a treatment focused on immediate results, it can be said to be a procedure suitable for those seeking gradual changes over time.

Q3. How many treatments are needed?

A. It varies depending on the symptoms and treatment area,

but for limited areas such as nasolabial folds, around 1–2 treatments,

while for extensive depressions or crater-like concerns, 2–3 treatments may be presented as a general guideline.

The final number of treatments will be determined individually through a consultation with a doctor.

Q4. Are there any side effects?

A. Temporary swelling, redness, or bruising may occur after the procedure,

but these are generally expected to subside within a few days.

However, since all medical procedures involve certain risks, it is important to receive a thorough explanation from your doctor in advance.

Q5. Can it also be done in Japan?

A. Clinics offering the procedure in Japan may sometimes be introduced, but the number is said to be limited.

Some people who place importance on the development background and number of cases may also consider undergoing the procedure in Korea.

Q6. Is post-procedure care necessary?

A. In many cases, no special aftercare is required, and

washing your face and applying makeup may be possible from the day of the procedure.

However, precautions vary depending on the procedure and your skin condition, so please follow your doctor's instructions.

Q7. Is there an age limit?

A. There is often no clearly defined age limit, but

it is said that many people who are beginning to be concerned about age-related changes, such as deep wrinkles and indentations consider the procedure.

Consultations are available for a wide range of age groups, from people in their late 20s to middle-aged and older adults.

Q8. Can men also undergo the procedure?

A. Yes, consultations and procedures are also available for men.

In recent years, more men are said to be considering cosmetic medical treatments due to concerns such as nasolabial folds and acne scars.

Summary: From temporary “replenishment” to “regeneration” as the next option✨

 What did you think?

JUVGEN is

one of the options introduced as a treatment that approaches concerns such as nasolabial folds and crater-like skin texture from a different perspective than conventional methods.

Many conventional aesthetic treatments have aimed to “supplement” or “temporarily improve” the skin,

and quite a few people have felt that there are limits to repeated care.

Through its action on the inside of the skin (the dermis),

JUVGEN is attracting attention as an approach that aims to bring out the skin’s natural changes.

It is said to be designed to utilize the body’s functions and support collagen production,

making it an option for those who wish to consider improvement from a medium- to long-term perspective, rather than focusing on short-term changes.

Features of JUVGEN (points generally introduced)

✅ Designed to work on the dermal environment and aim to bring out changes in the skin

✅ Said to make it easier to consider the duration of effects from a medium- to long-term perspective

✅ Patent acquisition in multiple countries and its technological background have been introduced

✅ Said to have been developed with the involvement of physicians with many years of clinical experience

✅ There are cases in which relatively little downtime is said to occur

✅ May be considered as an option for concerns such as deep wrinkles, depressions, and scars

※Indications, effects, duration, and downtime vary from person to person.

“I’m tired of repeatedly getting hyaluronic acid treatments”

“I’m looking for another possibility for my deep nasolabial folds”

“I have skin concerns that I feel can’t be improved any further”

For those people, it may be one option worth knowing about.

This treatment, said to have originated in Gangnam, South Korea,

is based on an approach that emphasizes changes from the foundation of the skin, rather than temporary results.

For concerns that have made you feel, “Maybe it’s already too difficult,”

it could be described as a technology with the potential to offer a new perspective.

If you are considering traveling to Korea,

one option is to confirm through an in-person consultation whether it is suitable for you.

Information to help you enjoy Korea more closely and with peace of mind――

brought to you by Yeppuriko, a reliable one-stop guide to Korea.